Description

Ksenia Malarkey, ND | The Estrogen Cost of Cancer Treatment: An Integrative Framework for Managing AI and ADT-Induced Deficiency in Breast and Prostate Cancer Survivors

Aromatase inhibitor therapy and androgen deprivation therapy produce severe iatrogenic estrogen deficiency in both women and men, driving arthralgia, bone loss, cardiometabolic decline, cognitive impairment, and sexual dysfunction. These consequences are common, debilitating, and rarely addressed in oncology follow-up. This session presents a systems-based naturopathic framework for assessing and treating AI and ADT-induced estrogen deficiency. Attendees will leave with actionable protocols across musculoskeletal, bone, cardiometabolic, and neurocognitive domains, plus evidence-informed guidance on localized hormone therapy, transdermal estradiol add-back in men informed by the PATCH trial, and the estrobolome and circadian signaling as upstream modulators.

——

Ksenia Malarkey, ND is a naturopathic physician specializing in integrative oncology, metabolic health, and hormonal medicine. Her clinical practice bridges conventional oncology and integrative medicine, with particular focus on the under-addressed physiologic consequences of cancer treatment including circadian disruption, endocrine depletion, and post-treatment allostatic load. She writes Integrative Oncology Insights, a publication translating emerging evidence into clinically applicable protocols for patients in active treatment and survivorship. Her clinical framework emphasizes mechanism-informed, patient-centered care that honors naturopathic roots while integrating advanced diagnostics and evidence-based intervention across hormonal, metabolic, and survivorship medicine.