Clinically assessing and integrating the genomic data (SNPs) with their activators (epigenetics)–How do we make this work?
All clinicians know that lab data are one piece of a bigger clinical puzzle. The seemingly endless amount of potential genomic data on SNP reports takes this consideration to a whole new level. From a mathematical perspective it is like having a new thyroid panel with 200 analytes to consider! Added to this is the fact that the presence of a SNP, whether heterozygous or homozygous, does not necessarily mean pathology or dysfunction are related. Using genomic principles and available data (but more importantly thousands of genomic case consultations) Dr. Anderson will break these issues down, give clinical tips on matching SNP results to related dysfunction and pathology as well as when to question and potentially dismiss such connections. The goal of this presentation is to have the practitioner leave with a “handle” on this crucial portion of genomic medicine in practice.
Integrating Genetic Health Reports into Clinical Practice
The genomic revolution is here. Genetic health reports synthesize patient genetic data into a health report format. These reports support whole-system medicine and bring personalized medicine to a higher level. While genetic health reports promise greater precision in directing patient treatment options, features and content vary widely. This presentation presents an overview of health report choices and demonstrates how to incorporate reports into a health care practice.
Mental Health: Genetics and Nutrigenomics
The field of genetics is exploding, and we are learning more and more about how a patient’s DNA may affect a person’s phenotype. Dr. Peter Bongiorno will review what we know about the field of genetics in relations to mental health. He will review epigenetic implications of methylation, histone acetylation and micro RNA processing, and then identify the genes that are all the rage in mental health (like COMT, MTHFR and DBH) and review many of the lesser known codes in our “book of life” (such as SLC3A4, PPAR’s, IDO, etc..) which also can have a strong say in the balance of inflammation, hormones, mitochondria, Â mood and mental health. He will explain the available research about how naturopathic influences, including diet, lifestyle, herbs, and supplements can play a helpful role to modulate mood genes, and change.
Generative Precision Medicine: Genome, Biome and Metabolome Integration
Integrating the even-increasing volume of personal health data into the real-time primary care environment is perhaps the biggest challenge facing naturopathic physicians. Â What is clear is that the old linear deterministic paradigms cannot cope and will not suffice. So what are our choices when the wave of personalized big data threatens to subsume us? We could run for the shore and pretend there are no such things as waves. We could stand firm (and probably get knocked over.) Or, we can ride the wave and see where it takes us. I believe that a systems (network) approach to precision medicine holds the promise of a truly objectified vis medicatrix naturae, a concept I have termed Generative Medicine. Generative theory produces a more informed naturopathic practice, using bioinformatics to produce high-information-value conclusions and identify possible interventions aligned to emergent trends. In this lecture we will explore tools for parsing an interaction web of disparate client data (SNP, taxon, small metabolite) into actionable ‘piecemeal approximations of reality’ for improved prediction, personalization, and prevention.
SNP Away Prostate Cancer: Preventing and Treating Prostate Cancer: A nutrigenomic approach
The objective of the presentation will be to identify various Single Nucleotide Polymorphisms (SNPs) and their implication in prostate cancer (CaP). Currently the screening for CaP with PSA is unreliable and controversial. Many men are now opting out of invasive CaP procedures (Chemo, radiation, ADT, prostatectomy) and deciding on Active Surveillance. This population of men most benefit from analyzing their genomic information to identify their risks for aggressive CaP and to tailor their treatment using nutrigenomics in their treatment, surveillance and prevention of CaP.Â Discussion on potentiating conventional treatments such as chemo and ADT via nutrigenomics will also be addressed.Â
Human Hookworm (Necator Americanus) and Induction of Genetic Immunotolerance In the Human Organism
Previously seen as a scourge to human populations, the members of the helminth family are now receiving increased attention as therapeutic agents. Necator Americanus, or the human hookworm, has been on the receiving end of much of the attention. As a relatively non-communicable organism, with low risk of organ invasion or colonization outside of the small intestine, some formal research and scholarly conjecture as to the therapeutic effects achieved by hookworms have recently been undertaken. This presentation will review current research, mechanisms, and current and potential therapeutics. Current conventional and naturopathic pharmacy will include a reassessment of therapeutic goals.
The Stress Remedy Meets Genetic SNPs: Integrating human and bacterial genomic information into clinical practice
My presentations usually dwell in the area of epigenetics – how stress exposure affects gene expression and health, and how we can address health issues by modifying both stress exposure and stress recovery. Over the past three years, my practice and approach has completed a total make-over in terms of integrating genetic assessment into the strategic plan for each case. By knowing SNPs and microbial genetics, we have been able to further individualize patient care. In this presentation, I will explain how we do that – what works and what doesn’t work. And the steps you can take to integrate genetic data into your clinical assessment and care.
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